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Thomas Efferth Selected Research

Doxorubicin (Adriamycin)

7/2022Cytotoxicity, acute and sub-chronic toxicities of the fruit extract of Tetrapleura tetraptera (Schumm. & Thonn.) Taub. (Fabaceae).
6/2022Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection.
10/2021Identification of Novel Anthracycline Resistance Genes and Their Inhibitors.
5/2021Bioactivity of fractions and constituents of Piper capense fruits towards a broad panel of cancer cells.
3/2021Cytotoxic phytochemicals from the crude extract of Tetrapleura tetraptera fruits towards multi-factorial drug resistant cancer cells.
3/2021Cytotoxicity of botanicals and isolated phytochemicals from Araliopsis soyauxii Engl. (Rutaceae) towards a panel of human cancer cells.
2/2021Cytotoxicity of fagaramide derivative and canthin-6-one from Zanthoxylum (Rutaceae) species against multidrug resistant leukemia cells.
1/2021The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis.
8/2020Cytotoxicity of a naturally occuring spirostanol saponin, progenin III, towards a broad range of cancer cell lines by induction of apoptosis, autophagy and necroptosis.
6/2020N-acetylglycoside of oleanolic acid (aridanin) displays promising cytotoxicity towards human and animal cancer cells, inducing apoptotic, ferroptotic and necroptotic cell death.
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Thomas Efferth Research Topics

Disease

328Neoplasms (Cancer)
08/2022 - 01/2002
96Leukemia
05/2022 - 03/2002
35Breast Neoplasms (Breast Cancer)
07/2022 - 01/2003
30Malaria
11/2021 - 12/2004
29Carcinoma (Carcinomatosis)
07/2022 - 01/2002
25Glioblastoma (Glioblastoma Multiforme)
11/2021 - 05/2003
20Inflammation (Inflammations)
07/2022 - 07/2010
18Neoplasm Metastasis (Metastasis)
07/2022 - 01/2002
16Carcinogenesis
02/2022 - 09/2010
14Infections
09/2021 - 12/2004
13Colonic Neoplasms (Colon Cancer)
02/2022 - 12/2005
13Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
12/2017 - 01/2002
11Necrosis
02/2021 - 06/2008
9Alzheimer Disease (Alzheimer's Disease)
09/2022 - 10/2015
9Melanoma (Melanoma, Malignant)
07/2022 - 12/2005
9Multiple Myeloma
04/2022 - 01/2002
8Pain (Aches)
06/2022 - 01/2013
8Adenocarcinoma
09/2019 - 07/2002
7Lung Neoplasms (Lung Cancer)
09/2022 - 02/2002
7Osteoarthritis
06/2022 - 11/2018
7Cardiotoxicity
01/2022 - 07/2004
7COVID-19
07/2021 - 01/2021
6Neuroinflammatory Diseases
09/2022 - 11/2018
6Glioma (Gliomas)
06/2022 - 03/2004
6Hepatocellular Carcinoma (Hepatoma)
01/2022 - 01/2013
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2022 - 02/2002
5Virus Diseases (Viral Diseases)
01/2022 - 08/2011
5Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2022 - 06/2015
5Prostatic Neoplasms (Prostate Cancer)
01/2022 - 07/2008
5Pancreatic Neoplasms (Pancreatic Cancer)
01/2012 - 08/2009
5Squamous Cell Carcinoma of Head and Neck
07/2011 - 09/2004
5Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
09/2010 - 01/2002
4Atherosclerosis
07/2022 - 01/2003
4Osteosarcoma (Osteogenic Sarcoma)
06/2022 - 01/2018
4Sarcoma (Soft Tissue Sarcoma)
01/2022 - 07/2006
4Heart Failure
01/2022 - 06/2015

Drug/Important Bio-Agent (IBA)

159Pharmaceutical PreparationsIBA
07/2022 - 07/2002
52ArtesunateIBA
07/2022 - 03/2002
50Member 1 Subfamily B ATP Binding Cassette TransporterIBA
07/2022 - 01/2003
49Proteins (Proteins, Gene)FDA Link
07/2022 - 01/2002
47Doxorubicin (Adriamycin)FDA LinkGeneric
07/2022 - 07/2002
39artemisinin (artemisinine)IBA
11/2021 - 08/2002
26ErbB Receptors (EGF Receptor)IBA
04/2022 - 05/2003
26PhytochemicalsIBA
01/2022 - 07/2011
24Antimalarials (Antimalarial Agents)IBA
07/2017 - 08/2003
23Biological ProductsIBA
04/2022 - 01/2008
23ATP-Binding Cassette Transporters (ABC Transporters)IBA
06/2021 - 12/2004
22resazurinIBA
06/2022 - 01/2012
22Messenger RNA (mRNA)IBA
06/2022 - 08/2002
19AntioxidantsIBA
08/2022 - 10/2003
14FlavonoidsIBA
07/2022 - 12/2011
13Methanol (Carbinol)IBA
05/2021 - 04/2011
13AlkaloidsIBA
01/2021 - 04/2010
13Plant ExtractsIBA
11/2019 - 03/2004
12Antiviral Agents (Antivirals)IBA
04/2021 - 04/2002
11TeaIBA
06/2022 - 09/2010
11EnzymesIBA
01/2022 - 08/2003
10Complex MixturesIBA
05/2022 - 08/2013
10DNA (Deoxyribonucleic Acid)IBA
11/2020 - 08/2003
10Antineoplastic Agents (Antineoplastics)IBA
01/2019 - 10/2010
9shikoninIBA
02/2022 - 01/2012
9CaspasesIBA
12/2021 - 08/2010
9ArtemisininsIBA
11/2021 - 07/2004
9Adenosine Triphosphate (ATP)IBA
07/2021 - 12/2004
9Reactive Oxygen Species (Oxygen Radicals)IBA
09/2018 - 11/2006
8Biomarkers (Surrogate Marker)IBA
07/2022 - 08/2010
8Transcription Factors (Transcription Factor)IBA
12/2021 - 04/2010
8Matrix Metalloproteinases (MMPs)IBA
09/2018 - 09/2010
7CytokinesIBA
07/2022 - 05/2003
7CurcuminIBA
04/2022 - 12/2009
7NaphthoquinonesIBA
01/2022 - 05/2010
7Tyrosine Kinase InhibitorsIBA
11/2021 - 03/2004
7AcidsIBA
03/2021 - 04/2015
7Volatile Oils (Essential Oils)IBA
01/2021 - 08/2009
7IronIBA
01/2020 - 10/2004
6Paclitaxel (Taxol)FDA LinkGeneric
07/2022 - 07/2008
6theabrowninIBA
06/2022 - 01/2016
6Phosphotransferases (Kinase)IBA
11/2021 - 04/2010
6Opioid Analgesics (Opioids)IBA
09/2021 - 01/2013
6Anti-Bacterial Agents (Antibiotics)IBA
01/2020 - 08/2003
6Cytostatic AgentsIBA
11/2019 - 01/2003
6Cantharidin (Cantharides)IBA
02/2014 - 03/2005
5CamptothecinIBA
07/2022 - 03/2008
5XenobioticsIBA
06/2021 - 01/2015
5ResveratrolIBA
01/2021 - 10/2009
5Plant Preparations (Preparation, Plant)IBA
01/2021 - 05/2015
5EstersIBA
01/2020 - 10/2013
5Chalcone (Benzalacetophenone)IBA
09/2019 - 09/2010
5multidrug resistance-associated protein 1IBA
03/2019 - 01/2003
5Arsenic Trioxide (Trisenox)FDA Link
01/2018 - 09/2004
5Erlotinib Hydrochloride (CP 358,774)FDA Link
12/2017 - 03/2004
4Interleukin-6 (Interleukin 6)IBA
07/2022 - 01/2002
4Peptide Hydrolases (Proteases)FDA Link
07/2021 - 09/2010
4RNA (Ribonucleic Acid)IBA
02/2021 - 01/2020

Therapy/Procedure

118Therapeutics
07/2022 - 04/2002
90Drug Therapy (Chemotherapy)
07/2022 - 03/2004
23Chinese Traditional Medicine (Traditional Chinese Medicine)
06/2022 - 03/2002
8Chemoprevention
09/2021 - 03/2006
6Radiotherapy
07/2022 - 03/2008
6Traditional Medicine (Folk Remedies)
03/2022 - 07/2007